IMIDAZOPYRAZINONE DERIVATIVES Russian patent published in 2018 - IPC C07D487/04 A61K31/4985 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds selected from the group

No Name “A1” 6-n-tolyl-7H-imidazo[1,5-a]pyrazin-8-one “A2” 6-(4-tert-butyl-phenyl)-7H-imidazo[1,5-a]pyrazin-8-one “A3” 6-(4-trifluoromethyl-phenyl)-7H-imidazo[1,5-a]pyrazin-8-one “A4” 6-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-7H-imidazo[1,5-a]pyrazin-8-one “A5” 6-(4-hydroxymethyl-phenyl)-7H-imidazo[1,5-a]pyrazin-8-one “A6” 6-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-7H-imidazo[1,5-a]pyrazin-8-one “A7” 6-(4-tert-butyl-phenyl)-3-methyl-7H-imidazo[1,5-a]pyrazin-8-one “A8” 6-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3-methyl-7H-imidazo[1,5-a]pyrazin-8-one

as well as to medicines based thereon.

EFFECT: obtaining novel compounds with inhibitory activity against tankyrase (TANK).

2 cl, 2 tbl, 8 ex