FIELD: chemistry.
SUBSTANCE: present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I): 
where ring A is a group represented by the formula: 
; ring B is a group represented by the formula: 
, provided that the links denoted by (*) are the binding site of the formula: 
; the links (**) are the binding site with ring A; the links denoted by (***) are the binding site with the formula: 
; R1 is C1-6alkyl or C1-6alkoxy; R2 and R3, each independently represent a hydrogen atom or methyl; n is 0, 1, 2, 3, 4, or 5; or a pharmaceutically acceptable salt thereof.
EFFECT: compounds possess NK1 receptor antagonist activity and which are useful for the prevention or treatment of anti-cancer chemotherapy induced by nausea or vomiting.
12 cl, 1 dwg, 14 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CYCLOHEXYLPYRIDINE DERIVATIVES | 2015 |
|
RU2681316C2 |
| DERIVATIVES OF 4-PHENYLPYRIDINE AND MEDICINAL AGENT BASED ON THEREOF | 2001 |
|
RU2277087C2 |
| PYRANODIPYRIDINE COMPOUND | 2016 |
|
RU2743998C2 |
| DERIVATIVES OF DIPHENYL AND MEDICINAL AGENT | 2000 |
|
RU2238266C2 |
| DERIVATIVES OF 3-PHENYLPYRIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2236402C2 |
| DERIVATIVES OF 4-PHENYLPYRIDINE AND MEDICINAL AGENT | 2001 |
|
RU2276139C2 |
| DERIVATIVES OF (3-METHYLPYRROLIDIN-3-YL)-METHYL PYRIDINYL ETHER AND THEIR USE AS ANTAGONISTS OF RECEPTOR NK-3 | 2011 |
|
RU2625798C2 |
| DERIVATIVES OF PIPERIDINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND TREATMENT METHOD | 2003 |
|
RU2294927C2 |
| 3-AZETHIDINYLALKYLPIPERIDINES OR PYRROLIDINES AS TACHYKININE ANTAGONISTS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT | 1996 |
|
RU2158264C2 |
| DOUBLE NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA | 2005 |
|
RU2374229C2 |
