DERIVATIVES OF PIPERIDINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND TREATMENT METHOD Russian patent published in 2007 - IPC C07D211/16 C07D211/44 C07D211/54 C07D211/58 C07D211/62 C07D401/04 C07D401/12 C07D405/12 C07D409/12 C07D417/04 C07D417/12 C07D473/34 A61K31/451 A61K31/454 A61K31/4545 A61K31/4709 A61P1/00 A61P7/00 A61P13/00 A61P25/00 A61P29/00 A61P37/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of piperidine of the general formula (I): or their pharmaceutically acceptable salts wherein rings A and B represent optionally substituted benzene rings; R¹ represents alkyl, hydroxyl, thiol, carbonyl, sulfinyl, unsubstituted or substituted sulfonyl group and others; R² represents hydrogen atom, hydroxyl, amino-group, alkyl, unsubstituted or substituted carbonyl group or halogen atom; Z represents oxygen atom or group -N(R³)- wherein R³ and R⁴ represent hydrogen atom or alkyl group under condition that N-acetyl-1-benzyloxycarbonyl-2-phenyl-4-piperidineamine is excluded. Compounds of the formula (I) or their salts possess antagonistic activity with respect to tachykinin NK1-receptors and can be used in medicine in treatment and prophylaxis of inflammatory, allergic diseases, pain, migraine, diseases of central nervous system, digestive organs and others.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved method of treatment.

18 cl, 138 tbl, 527 ex