CYCLOHEXYLPYRIDINE DERIVATIVES Russian patent published in 2019 - IPC C07D213/75 A61K31/4418 A61P1/08 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I):[Chem. formula 1] (I), where ring A is a group represented by the following formula: [Chem. formula 2] or , X represents a hydrogen atom, cyano, halogen, C_1-6alkyl or hydroxymethyl; R¹ is a group represented by the following formula: [Chem. formula 3] or , where R^1a and R^1b, each independently of one another, represents a hydrogen atom or C_1-6alkyl; m is 0, 1 or 2; when m is 2, then R^1a and R^1b not necessarily different from each other; R² represents C_1-6alkyl or hydroxy; U is a group represented by the following formula: [Chem. formula 4] , where R^3a and R^3b, each independently, represents a hydrogen atom, C_1-6alkyl or hydroxyC_1-6alkyl; Y is 0 or 1; or its pharmaceutically acceptable salts, which have antagonistic activity against the receptor NK₁.

EFFECT: prevention or treatment of cancer-chemotherapy-induced nausea and vomiting.

12 cl, 1 dwg, 22 tbl, 7 ex