FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, specifically to nephrology, and can be used to treat kidney disease. Pharmaceutical compositions of the invention include a ROBO2 inhibitor.
EFFECT: use of inventions enables to treat kidney disease, accompanied by a change in the structure of the podocyte legs, due to the normalisation of this structure under the influence of the ROBO2 inhibitor on the SLIT-ROBO2 signalling pathway and negative regulation of the polymerisation of the podocyte F-actin cytoskeleton.
24 cl, 4 tbl, 8 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND THEIR USE | 2018 |
|
RU2791486C2 |
| COMPOSITION FOR PREVENTING OR TREATING RENAL DISEASES, CONTAINING DPP-IV INHIBITOR | 2014 |
|
RU2652343C2 |
| VAP-1 INHIBITORS ADMINISTRATION FOR FIBROID DISEASES TREATMENT | 2010 |
|
RU2667963C1 |
| USE OF VAP-1 INHIBITORS FOR FIBROTIC SICKNESS TREATMENT | 2010 |
|
RU2580626C2 |
| METHOD FOR PREDICTION OF PESPONSE RATE TO IMMUNOSUPPRESSIVE THERAPY OF CHRONIC GLOMERULONEPHRITIS WITH NEPHROTIC SYNDROME | 2011 |
|
RU2453852C1 |
| NEUROENDOCRINE FACTORS FOR TREATING DEGENERATIVE DISORDERS | 2008 |
|
RU2496790C2 |
| ALPORT SYNDROME TREATMENT OPTIONS | 2018 |
|
RU2791694C2 |
| METHOD OF TREATING NEPHROPATHY | 2014 |
|
RU2718054C2 |
| PREDICTIVE BIOMARKERS AND BIOMARKER SIGNS OF RENAL INTEGRITY TO BE USED IN KIDNEY HEALTH MONITORING | 2008 |
|
RU2519148C2 |
| ORGANOIDS CONTAINING ISOLATED RENAL CELLS, AND THEIR USE | 2014 |
|
RU2722361C2 |
