FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, specifically to nephrology, and can be used to treat kidney disease. Pharmaceutical compositions of the invention include a ROBO2 inhibitor.
EFFECT: use of inventions enables to treat kidney disease, accompanied by a change in the structure of the podocyte legs, due to the normalisation of this structure under the influence of the ROBO2 inhibitor on the SLIT-ROBO2 signalling pathway and negative regulation of the polymerisation of the podocyte F-actin cytoskeleton.
24 cl, 4 tbl, 8 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND THEIR USE | 2018 |
|
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| ALPORT SYNDROME TREATMENT OPTIONS | 2018 |
|
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| USE OF VAP-1 INHIBITORS FOR FIBROTIC SICKNESS TREATMENT | 2010 |
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| ANTIBODIES TO CD38 AND PHARMACEUTICAL COMPOSITIONS BASED THEREON FOR TREATMENT OF AUTOIMMUNE DISEASE MEDIATED BY AUTOANTIBODIES | 2020 |
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RU2809565C2 |
