PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF Russian patent published in 2019 - IPC C07D403/12 A61K31/506 A61P35/00 A61P29/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a novel compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I)

W is selected from a group consisting of: F, Cl, Br, I, CN, C₁-C₄alkyl, C₁-C₆alkoxy, CF₃, CHF₂, CH₂F, CON(R¹)R²; R¹ and R² are hydrogen; Ar is 5–6 membered heteroaryl with 1 or 2 nitrogen atoms in a ring or phenyl, each substituted with 0 to 2 substituents independently selected from a group consisting of (1) halogen and alkoxycarbonyl; and (3) groups of formula (Ia):

(Ia),

in which R₄ is hydrogen or C₁-C₄alkyl; XR₃ is CH; or XR₃ is O; or X is N, and R₃ is hydrogen, C₁-C₆alkyl, C₂-C₆alkanoyl, each of which is substituted with 0 to 2 substitutes independently selected from halogen and amino; R₅ and R₆ are independently selected from a group consisting of: hydrogen, F, Cl and Br; and R₇, R8 and R9 are independently selected from a group consisting of: hydrogen and C1-C4alkyl.

EFFECT: compound has the properties of an Abl-kinase, Alk-kinase, c-Src-kinase, FGFR1-kinase, KDR-kinase, Ret-kinase, Tie2-kinase and p-FGFR2 inhibitor and can be used in treating a disease or condition characterized by an undesired cell proliferation or hyperproliferation; in particular, can be used for treating and/or preventing proliferative disorder, cancer, tumour, inflammatory disease, autoimmune disease or immunologically related disease.

6 cl, 2 tbl, 68 ex