METHOD FOR FORECASTING THE DEVELOPMENT OF NEPHRITIS IN INDUCED MODEL OF SYSTEMIC LUPUS ERYTHEMATOSUS Russian patent published in 2018 - IPC G09B23/28 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention relates to experimental medicine and concerns the prediction of the development of nephritis in an induced model of systemic lupus erythematosus (SLE). Method consists in the fact that healthy female mice-hybrids (C57BL/6xDBA2)F1 are intraperitoneally injected with lipopolysaccharide at a dose of 0.5 mcg/kg. Then, after 24 hours, the SLE model is induced by intravenous injection of spleen cells of mice of the female DBA/2 line. On the 4^th and 8^th week from the moment of induction of SLE, the index of the ratio of neutrophils to blood lymphocytes (N/L) is determined and, with a significant increase in the value of N/L at the 8^th week relative to the 4^th week from the moment of induction of SLE, the development of nephritis is predicted.

EFFECT: method for predicting the development of nephritis is proposed.

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