FIELD: chemistry.
SUBSTANCE: invention relates to (6-{[(1S)-1(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]amino}-9H-purin-9-yl)methyl acetate (compound of formula I) with properties of inhibitor of p110δ – delta isoform of phosphoinositide-3-kinase (PI3K). In addition, invention relates to a method for producing a compound of formula I, an active ingredient, a pharmaceutical composition, and a drug based on it.
EFFECT: invention may be applicable to the treatment of follicular lymphoma and other malignant lymphoproliferative diseases from a number of non-Hodgkin lymphomas.
10 cl, 4 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CHROMENE DERIVATIVES AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | 2016 |
|
RU2722383C2 |
| DEUTERATED QUINAZOLINONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 2015 |
|
RU2656485C2 |
| NEW QUINAZOLIONIC DERIVATIVES INHIBITING PI3K, AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | 2017 |
|
RU2702904C1 |
| PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | 2013 |
|
RU2658006C2 |
| COMBINED TREATMENT BY A TOLL-LIKE RECEPTOR (TLR7) AGONIST AND A HEPATITIS B VIRUS CAPSID ASSEMBLY INHIBITOR | 2016 |
|
RU2718917C2 |
| PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | 2015 |
|
RU2695374C2 |
| PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | 2013 |
|
RU2661896C2 |
| 1-(3-AMINOPROPYL)-SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 2014 |
|
RU2671179C2 |
| CHEMICAL COMPOUNDS-759 | 2008 |
|
RU2481348C2 |
| PYRIMIDINE-SUBSTITUTED PURINE DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD OF PROTEIN KINASE INHIBITION, METHOD OF TREATING OR PREVENTING DISEASES SENSITIVE TO PROTEIN KINASE INHIBITION AND METHOD OF TREATING PROLIFERATIVE DISEASES | 2008 |
|
RU2518098C2 |
