CHROMENE DERIVATIVES AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS Russian patent published in 2020 - IPC C07D405/12 C07D473/34 C07D487/04 A61K31/353 A61K31/506 A61K31/519 A61K31/52 A61P9/00 A61P11/00 A61P25/28 A61P29/00 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), R₁ and R₂ are both H or combined to form an oxo group (=O); R₃ and R₄, identical or different, in each case independently selected from the group consisting of H and (C₁-C₆)alkyl; R₅ is selected from a group consisting of phenyl and heteroaryl with 5 ring atoms, in which one ring atom is a heteroatom S, where heteroaryl is substituted with one group selected from (C₁-C₆)hydroxyalkyl, dimethylaminomethyl, (4-methylpiperazin-1-yl) methyl; Z is absent or is NH; Cy is a mono- or bicyclic heteroaryl with 5–9 ring atoms, in which two or four ring atoms are a N heteroatom, where said heteroaryl is optionally substituted with two groups, selected independently from -CN, NR₁₀R₁₁, phenyl and heteroaryl, which is pyridinyl; where said phenyl and heteroaryl are additionally optionally and independently substituted with one or two groups, selected from halogen, -OH, -CN; and wherein said heteroaryl is further optionally substituted with group of 2,2,2-trifluoroethane-1-ol; where R₁₀, R₁₁ are selected from a group consisting of H. Invention also relates to pharmaceutical compositions.

EFFECT: obtaining novel compounds of formula (I), having inhibitory activity on phosphoinositide-3-kinase (PI3K), and which can be used as a drug for treating disorders caused by mechanisms of PI3K enzymes.

16 cl, 13 ex