1-(3-AMINOPROPYL)-SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Russian patent published in 2018 - IPC C07D401/14 C07D409/14 C07D417/14 C07D451/04 A61K31/454 A61K31/4545 A61K31/46 A61P31/18 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I wherein W is -CH₂CH₂-; X is N or CR₆; R₁ is selected from 5-6 membered heteroaryl, unsubstituted or substituted with 1 to 3 substituents, wherein said heteroaryl contains from 1 to 2 heteroatoms selected from a sulphur or nitrogen atom, and each of said substituents is independently selected from a halogen atom, straight or branched C1-C4 alkyl, straight or branched C1-C4 alkoxy, -NR₁₀R₁₁, -C(=O)R₁₂, straight or branched C1-C4 alkanoyloxy, cyano, nitro, or two adjacent substituents together with the attached carbon atom form a 6-membered aromatic ring, a 5-membered saturated ring or a 5-membered heterocyclic ring containing 2 heteroatoms selected from an oxygen atom; R₂ is selected from the following groups, unsubstituted or substituted with 1 to 3 substituents: straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, a 6-membered heterocyclic group containing 1 heteroatom selected from a nitrogen atom, C6-aryl; wherein said substituent is selected from the group consisting of a halogen atom, straight or branched C1-C4 alkyl, straight or branched C1-C4 alkylsulphonyl group, tetrazolyl, cyano; each of R₃, R₄ and R₅ is independently selected from the group consisting of H, straight or branched C1-C6 alkyl; values of other radicals are given in the patent claim. Invention also relates to a production method, a pharmaceutical composition and to the use of the compound. .

EFFECT: technical result: obtaining novel compounds of formula I, which have the properties of a CCR5 antagonist and can be used to treat human immunodeficiency virus (HIV) infection.

10 cl, 13 tbl, 181 ex