NEW QUINAZOLIONIC DERIVATIVES INHIBITING PI3K, AND PHARMACEUTICAL COMPOSITION CONTAINING THEM Russian patent published in 2019 - IPC C07D487/04 A61K31/52 A61P35/00 A61P1/16

Abstract RU 2702904 C1

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a novel quinazolinone derivative of formula 1, having PI3K inhibitor properties. Hematologic malignant tumor is leukemia or lymphoma. Hepatic disease is selected from a group consisting of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic steatosis, hepatocirrhosis, hepatitis, hepatic adenoma, hypersensitivity to insulin and liver cancer. In formula 1

X is halogen or -CH₃; and Y is C_3-4 cycloalkyl.

EFFECT: compound can be used for preventing or treating hematological malignant tumor, liver disease or autoimmune disease.

4 cl, 9 dwg, 3 tbl, 6 ex

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RU 2 702 904 C1

Authors

Kim, Jong-Woo

Lee, Chi-Woo

Hong, Su-Ji

Dates

2019-10-14—Published

2017-07-13—Filed