Show metadata Hide metadata

(19)

(11)

2 604 490

(13)

(51)

IPC

C07K16/46(2006-01-01)

A61P37/06(2006-01-01)

A61P35/00(2006-01-01)

A61K39/395(2006-01-01)

C07K16/00(2006-01-01)

C12N15/13(2006-01-01)

(21) (22)

Application

2013124423/10, 2011-11-04

(24)

Start date

2011-11-04

(22)

Actual filing date

2011-11-04

(45)

Published

2016-12-10

(72)

Inventor

Kabrera Erik EskobarShpreter Fon Kredenshtajn TomasDiksit Serzhit BimaraoLario Pola IrenPun Devid Kaj JuenD'Andzhelo Igor Edmondo Paolo

(73)

Holder

Zajmvorks Ink.

DESIGN OF STABLE HETERODIMERIC ANTIBODY WITH MUTATIONS IN Fc DOMAIN Russian patent published in 2016 - IPC C07K16/46 A61P37/06 A61P35/00 A61K39/395 C07K16/00 C12N15/13

Abstract RU 2604490 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry. Carcasses are described, which contain heavy chains, being asymmetric in different domains (for example, CH2 and CH3), to achieve selectivity between different Fc receptors involved in modulation of effector function, higher selectivity than selectivity, achieved when using natural homodimeric (symmetrical) Fc molecules, and increased stability and purity of produced alternative Fc homodimers as a result.

EFFECT: these new molecules contain complexes of heterogeneous components formed in order to change the behavior of natural antibodies and their use in medicinal agents.

80 cl, 38 dwg, 12 tbl, 8 ex

Similar patents RU2604490C2

Title	Year	Author	Number
DEVELOPMENT OF STABLE HETERODIMERIC ANTIBODY WITH MUTATIONS IN Fc DOMAIN	2012	Shpreter Fon Kredenshtajn, Tomas Diksit, Serzhit Bkhimarao Eskobar-Kabrera, Erik Lario, Pola Iren Pun, Devid Kaj Yuen	RU2810540C2
STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN Fc DOMAIN	2012	Shpreter Fon Kredenshtajn Tomas Diksit Serzhit Bimarao Lario Pola Iren Pun Devid Kaj Yuen Eskobar-Kabrera Erik	RU2675319C2
BISPECIFIC ASYMMETRIC HETERODIMERS COMPRISING ANTI-CD3 CONSTRUCTS	2013	Dixit Surjit Bhimarao Spreter Von Kreudenstein Thomas Ng Gordon Yiu Kon Weisser Nina E.	RU2650868C2
HETEROMULTIMERS WITH REDUCED OR SILENCED EFFECTOR FUNCTION	2014	Escobar-Cabrera Eric	RU2655439C2
ENGINEERED MULTI-SPECIFIC ANTIBODIES AND OTHER MULTIMERIC PROTEINS WITH ASYMMETRIC MUTATIONS IN THE CH2-CH3 REGION	2018	Chiu, Mark Zvolak, Adam	RU2804031C2
Fc-RECEPTOR BINDING MODIFIED ASYMMETRIC ANTIBODIES AND METHODS OF USE	2014	Regula Jerg Tomas Shefer Volfgang Shlotauer Tilman	RU2687043C2
EMBODIMENTS OF Fc-REGION WITH MODIFIED BINDING PROPERTIES OF FcRn AND PROTEIN A	2015	Shlotauer Tilman	RU2713131C1
VARIANTS OF Fc-DOMAIN WITH MODIFIED FcRn BINDING AND METHODS OF APPLICATION THEREOF	2015	Messner Ekkekhard Shlotauer Tilman	RU2714116C2
VARIANTS OF Fc-REGION WITH IMPROVED ABILITY TO BIND TO PROTEIN A	2015	Shlotauer Tilman	RU2698969C2
PREFERENTIAL PAIRING OF ANTIBODY DOMAIN	2018	Ryuker, Florian Benish, Maksimilian	RU2792440C2

RU 2 604 490 C2

Authors

Kabrera Erik Eskobar

Shpreter Fon Kredenshtajn Tomas

Diksit Serzhit Bimarao

Lario Pola Iren

Pun Devid Kaj Juen

D'Andzhelo Igor Edmondo Paolo

Dates

2016-12-10—Published

2011-11-04—Filed