FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Carcasses are described, which contain heavy chains, being asymmetric in different domains (for example, CH2 and CH3), to achieve selectivity between different Fc receptors involved in modulation of effector function, higher selectivity than selectivity, achieved when using natural homodimeric (symmetrical) Fc molecules, and increased stability and purity of produced alternative Fc homodimers as a result.
EFFECT: these new molecules contain complexes of heterogeneous components formed in order to change the behavior of natural antibodies and their use in medicinal agents.
80 cl, 38 dwg, 12 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DEVELOPMENT OF STABLE HETERODIMERIC ANTIBODY WITH MUTATIONS IN Fc DOMAIN | 2012 |
|
RU2810540C2 |
| STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN Fc DOMAIN | 2012 |
|
RU2675319C2 |
| BISPECIFIC ASYMMETRIC HETERODIMERS COMPRISING ANTI-CD3 CONSTRUCTS | 2013 |
|
RU2650868C2 |
| HETEROMULTIMERS WITH REDUCED OR SILENCED EFFECTOR FUNCTION | 2014 |
|
RU2655439C2 |
| ENGINEERED MULTI-SPECIFIC ANTIBODIES AND OTHER MULTIMERIC PROTEINS WITH ASYMMETRIC MUTATIONS IN THE CH2-CH3 REGION | 2018 |
|
RU2804031C2 |
| Fc-RECEPTOR BINDING MODIFIED ASYMMETRIC ANTIBODIES AND METHODS OF USE | 2014 |
|
RU2687043C2 |
| EMBODIMENTS OF Fc-REGION WITH MODIFIED BINDING PROPERTIES OF FcRn AND PROTEIN A | 2015 |
|
RU2713131C1 |
| VARIANTS OF Fc-DOMAIN WITH MODIFIED FcRn BINDING AND METHODS OF APPLICATION THEREOF | 2015 |
|
RU2714116C2 |
| VARIANTS OF Fc-REGION WITH IMPROVED ABILITY TO BIND TO PROTEIN A | 2015 |
|
RU2698969C2 |
| MODIFIED ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS AND USE THEREOF | 2015 |
|
RU2832921C1 |
