FIELD: biotechnology.
SUBSTANCE: heterodimeric Fc constructs have been proposed to impart thermostability to the antibody. Fc constructs are based on human IgG1 and contain modified CH3 domains including amino acid modifications compared to the wild-type CH3 domain polypeptide. Heat-stable antibodies containing these Fc constructs are also proposed.
EFFECT: invention provides increased stability and purity of the obtained Fc heterodimer variants.
18 cl, 52 dwg, 16 tbl, 15 ex
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