RECOMBINANT STRAIN OF YEAST HANSENULA POLYMORPHA - PRODUCENT OF CAPSID PROTEIN OF HEPATITIS E VIRUS Russian patent published in 2013 - IPC C12N1/19 C12N15/51 C07K14/02 C12R1/78 

FIELD: biotechnologies.

SUBSTANCE: strain of yeast Hansenula polymorpha is proposed - a producent of a recombinant capsid protein of hepatitis E virus E (HEV) of genotype 3. The strain was produced by integration of a DNA sequence into a yeast cell genome, and this sequence codes the fragment of the amino acid sequence from 86 to 607 position of the capsid protein of the hepatitis E virus of genotype 3 (rtHEV-ORF2) under control of the MOX gene promotor. The strain provides for high yield of the recombinant protein rtHEV-ORF2 with simplified methods for production of high-density cultures.

EFFECT: invention may be used for microbiological production of a recombinant protein rtHEV-ORF2, having immunogenic properties of a natural protein.

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