FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Genetic construct of pCXC8R-Fc is proposed, containing early human cytomegalovirus (CMV) promoter, CD33 leader sequence, interleukin-8 receptor extracellular domain, factor Xa recognition site, human immunoglobulin G1 Fc fragment, synthetic intron IVS, internal ribosome landing site of encephalomyocarditis virus (IRES), Neo(R), the SV40 virus polyadenylation signal sequence, ColE1 replication origin, Amp(R).
EFFECT: present invention can be used to generate protein consisting of extracellular domain of interleukin receptor 8 and Fc fragment of human immunoglobulin G1 and having properties to block interleukin-8 (IL-8) activity.
1 cl, 4 dwg, 6 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MAT40 ANTIBODY BINDING WITH DOMAIN I OF EXTRACELLULAR PART OF EPIDERMAL HER2/CD340 GROWTH FACTOR RECEPTOR, AND ITS APPLICATION FOR CANCER TREATMENT | 2015 |
|
RU2640259C2 |
| EXPRESSION PLASMID VECTORS FOR EXPRESSION OF TNFR1-Fc ACTIVE FORM, AND METHODS FOR RECOMBINANT PROTEINS PRODUCTION | 2016 |
|
RU2625010C1 |
| RECOMBINANT PLASMID DNA pFastBac-G2R-IgG, WHICH CONTAINS FRAGMENT OF SMALLPOX VIRUS GENOME, CODING FACTOR OF TUMOUR NECROSIS, BINDING PROTEIN, AND FRAGMENT OF HUMAN GENOME, CODING SECTION OF HEAVY CHAIN OF ANTIBODY G, AND STRAIN OF BACULOVIRUS BvG2RIgG, WHICH PRODUCES SOLUBLE CHIMERIC PROTEIN, WHICH CONSISTS OF SMALLPOX VIRUS PROTEIN, BINDING FACTOR OF TUMOUR NECROSIS, AND FRAGMENT OF HEAVY CHAIN OF HUMAN ANTIBODY G | 2008 |
|
RU2376375C2 |
| ANTIBODIES AGAINST HUMAN STABILIN-1 RECEPTOR | 2023 |
|
RU2823309C1 |
| NUCLEOTIDE SEQUENCE CODING FUSION PROTEIN CONSISTING OF SOLUBLE EXTRACELLULAR FRAGMENT OF HUMAN IL-6R AND CONSTANT PART OF HEAVY CHAIN OF HUMAN IGG4 | 2023 |
|
RU2818329C1 |
| METHOD FOR OBTAINING OF RECOMBINANT PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN (PAL) LEGIONELLA PNEUMOPHILA | 2016 |
|
RU2634385C1 |
| CHEMERIC IMPROVED RECOMBINANT FACTOR VIII | 2015 |
|
RU2647769C2 |
| ENHANCEMENT OF IMMUNE RESPONSES MEDIATED BY PROTEINS FUSED FROM ANTIBODY AND CYTOKINE BY METHOD OF COMBINED ADMINISTRATION OF ANGIOGENESIS INHIBITOR | 1999 |
|
RU2229305C2 |
| METHOD TO OBTAIN CHEMERIC RECOMBINANT PROTEIN fliC:pagN | 2015 |
|
RU2627602C2 |
| NUCLEOTIDE SEQUENCE CODING FUSED PROTEIN CONSISTING OF FUNCTIONAL FRAGMENT OF HUMAN IL-1RA AND CONSTANT PART OF HEAVY CHAIN OF HUMAN IgG4 | 2023 |
|
RU2821896C1 |
