METHOD OF QUANTITATIVE DETERMINATION OF 8-(TRIFLUOROMETHYL)BENZO[f][1,2,3,4,5]PENTATHIEPIN-6-AMINE HYDROCHLORIDE IN BIOLOGICAL MEDIA Russian patent published in 2018 - IPC G01N33/49

Abstract RU 2676487 C1

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely pharmacology and toxicology, and can be used to determine 8-(trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-amine hydrochloride in biological media. Method involves the extraction of the analyte with a 0.4 % solution of formic acid in acetonitrile, followed by its determination by high-performance liquid chromatography-mass spectrometry with isocratic elution mode using as the mobile phase a mixture of a solution of trifluoroacetic acid and a 0.1 % solution of formic acid in methanol in a ratio of 20:80.

EFFECT: using this method allows you to determine the quantitative content of 8-(trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-amine hydrochloride to study the pharmacokinetics of the drug on the basis of this substance.

1 cl, 3 tbl, 4 ex

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RU 2 676 487 C1

Authors

Leonov Klim Andreevich

Dates

2018-12-29—Published

2018-06-27—Filed