FIELD: measurement technology.
SUBSTANCE: invention relates to a method for quantitative determination of disulphiram in biological media, involving extraction of the substance to be determined with ethyl acetate from biological tissue with subsequent determination thereof by high-performance liquid chromatography-mass spectrometry with a gradient elution mode using 0.1 % solution of formic or acetic acid in water as a mobile phase and 0.1 % solution of formic or acetic acid in methanol or acetonitrile.
EFFECT: method enables quantitative determination of disulphuram in various biological tissues.
1 cl, 1 dwg, 9 tbl, 9 ex
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