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2 581 060

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IPC

C07D341/00(2006-01-01)

A61K31/385(2006-01-01)

A61P25/28(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014139787/04, 2014-09-30

(24)

Start date

2014-09-30

(22)

Actual filing date

2014-09-30

(45)

Published

2016-04-10

(72)

Inventor

Khomenko Tatjana MikhajlovnaVolcho Konstantin PetrovichZakharenko Aleksandra LeonidovnaZhukova Svetlana ViktorovnaAnarbaev Rashid OktamovichLavrik Olga IvanovnaSalakhutdinov Nariman Faridovich

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Khimicheskoj Biologii I Fundamentalnoj Meditsiny Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

AGENT FOR INHIBITING HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME Russian patent published in 2016 - IPC C07D341/00 A61K31/385 A61P25/28 A61P35/00

Abstract RU 2581060 C1

FIELD: biotechnology; biochemistry.

SUBSTANCE: invention relates to a known compounds representing derivatives (8-(trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-yl)amides of general formula I, having ability to inhibit human enzyme tyrosyl-DNA-phosphodiesterase 1.

EFFECT: increased inhibitory action on enzyme of human tyrosyl-DNA-phosphodiesterase 1 (Tdp1) and wider range of inhibitors of this enzyme.

1 cl, 2 dwg, 1 tbl, 8 ex

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RU 2 581 060 C1

Authors

Khomenko Tatjana Mikhajlovna

Volcho Konstantin Petrovich

Zakharenko Aleksandra Leonidovna

Zhukova Svetlana Viktorovna

Anarbaev Rashid Oktamovich

Lavrik Olga Ivanovna

Salakhutdinov Nariman Faridovich

Dates

2016-04-10—Published

2014-09-30—Filed