FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns an immunotoxin for the treatment of multiple sclerosis, which is a recombinant protein, including the A-subunit of viscumin and a fragment of myelin-oligodendrocyte glycoprotein linked by a linker for binding these fragments. Group of inventions also relates to recombinant plasmid DNA for expression in Escherichia coli cells of the gene encoding said immunotoxin; concerns a method for producing an immunotoxin; concerns a method of treating multiple sclerosis, consisting in the intravenous administration of a pharmaceutical composition containing the indicated immunotoxin, in a therapeutically effective amount.
EFFECT: group of inventions provides immunotoxin for the treatment of multiple sclerosis with high specificity and low toxicity.
19 cl, 9 dwg, 3 tbl, 1 ex
| Title |
Year |
Author |
Number |
| SUBSTANCES AND METHODS OF TREATING MULTIPLE SCLEROSIS MEDIATED BY B CELLS |
2009 |
|
RU2522251C2 |
| PLASMID FOR EXPRESSION IN BACTERIA CELLS OF GENUS Escherichia OF INACTIVE PRECURSOR OF MUTEIN [C112S] OF HUMAN ENTEROKINASE LIGHT CHAIN, BACTERIA BELONGING TO GENUS Escherichia, - PRODUCER OF PRECURSOR OF RECOMBINANT MUTEIN [C112S] OF HUMAN ENTEROKINASE LIGHT CHAIN, PRECURSOR OF RECOMBINANT MUTEIN [C112S] OF HUMAN ENTEROKINASE LIGHT CHAIN, METHOD OF PRODUCTION OF RECOMBINANT MUTEIN [C112S] OF HUMAN ENTEROKINASE LIGHT CHAIN, RECOMBINANT MUTEIN [C112S] OF HUMAN ENTEROKINASE LIGHT CHAIN |
2011 |
- Orlova Nadezhda Aleksandrovna
- Vorob'Ev Ivan Ivanovich
- Matskevich Viktor Aleksandrovich
- Zvjagin Ivan Vladimirovich
|
RU2495934C2 |
| RECOMBINANT PLASMID DNA pQe30_PS-CFP2/TurboYFP_MBP7, CODING PROTEIN PS-CFP2/TurboYFP_MBP7, STRAIN OF Escherichia coli BL21(DE3)/pQe30_PS-CFP2/TurboYFP_MBP7 - SAID PROTEIN PRODUCENT AND METHOD OF OBTAINING PROTEIN PS-CFP2/TurboYFP_MBP7 |
2009 |
- Gabibov Aleksandr Gabibovich
- Belogurov Aleksej Anatol'Evich
- Ponomarenko Natal'Ja Aleksandrovna
- Zakharova Marija Jur'Evna
- Miroshnikov Anatolij Ivanovich
|
RU2430161C2 |
| POLYNUCLEOTIDE ENCODING MUTANT RECOMBINANT IgA1 PROTEASE OF Neisseria meningitidis OF SEROGROUP B, RECOMBINANT PLASMID DNA COMPRISING SAID POLYNUCLEOTIDE, HOST CELL CONTAINING SAID PLASMID DNA, RECOMBINANT IgA1 PROTEASE OF Neisseria memingitidis OF SEROGROUP B, METHOD OF PRODUCING MATURE FORM OF IgA1 PROTEASE |
2011 |
- Rumsh Lev Davydovich
- Serova Oksana Viktorovna
- Zinchenko Aleksej Alekseevich
- Alliluev Aleksandr Pavlovich
- Kozlov Leonid Vasil'Evich
- Kotel'Nikova Ol'Ga Viktorovna
- Zhigis Larisa Stefanovna
- Jagudaeva Elena Jur'Evna
- Andina Svetlana Semenovna
- Anokhina Irina Viktorovna
- Zueva Vera Sergeevna
- Gordeeva Elena Anatol'Evna
- Melikhova Tat'Jana Dmitrievna
- Nokel' Elena Adamovna
|
RU2486243C1 |
| RECOMBINANT PLASMID pPA-OPRF-ATOX-OPRI DNA, WHICH ENCODES SYNTHESIS OF HYBRID RECOMBINANT PROTEIN, INCLUDING AMINO ACID SEQUENCES OF PROTEIN F AND I OF EXTERNAL MEMBRANE AND ATOXIC VARIANT OF A PSEUDOMONAS AERUGINOSA EXOTOXIN, ESCHERICHIA COLI PA-OPRF-ATOX-OPRI STRAIN - PRODUCER OF HYBRID RECOMBINANT PROTEIN AND METHOD OF OBTAINING SPECIFIED PROTEIN |
2017 |
- Kaloshin Aleksej Alekseevich
- Zimina Ekaterina Maksimovna
- Mikhajlova Natalya Aleksandrovna
|
RU2677790C1 |
| HUMAN ENDOSTATIN PREPARATION AND METHOD FOR PRODUCTION THEREOF |
2004 |
- Gorokhovets Neonila Vasil'Evna
- Digtjar' Anton Vasil'Evich
- Korzhenevskij Dmitrij Andreevich
- Lutsenko Elena Valer'Evna
- Lutsenko Sergej Viktorovich
- Makarov Vladimir Alekseevich
- Pozdnjakova Natal'Ja Vladimirovna
- Severin Evgenij Sergeevich
- Severin Sergej Evgen'Evich
- Solov'Ev Andrej Ivanovich
- Fel'Dman Natalija Borisovna
|
RU2278688C1 |
| OPTIMIZED RECOMBINANT PROTEIN ENCODING GENE - HUMAN INTERFERON BETA ANALOG |
2015 |
- Martynov Aleksandr Igorevich
- Gasanov Vagif Ali Ogly
- Shevale Aleksandr Fedorovich
- Khaitov Rakhim Musaevich
|
RU2614264C2 |
| RECOMBINANT HYBRID POLYPEPTIDE, CAPABLE OF INHIBITING HUMAN ENDOTHELIAL CELL PROLIFERATION IN VITRO, AND METHOD FOR PRODUCTION THEREOF |
2011 |
- Svistunov Andrej Alekseevich
- Lutsenko Sergej Viktorovich
- Fel'Dman Natalija Borisovna
- Solov'Ev Andrej Ivanovich
|
RU2465283C1 |
| NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES |
2011 |
- Rumsh Lev Davydovich
- Mel'Nikov Ehdvard Ehduardovich
- Alliluev Aleksandr Pavlovich
- Kozlov Leonid Vasil'Evich
- Kotel'Nikova Ol'Ga Viktorovna
- Zhigis Larisa Stefanovna
- Serova Oksana Viktorovna
- Jagudaeva Elena Jur'Evna
- Bichucher Anna Mironovna
- Zubov Vitalij Pavlovich
- Anokhina Irina Viktorovna
- Zueva Vera Sergeevna
- Avakov Anatolij Ehduardovich
|
RU2453599C1 |
| GENE-CELL VESICULAR THERAPEUTIC DRUG AND METHOD FOR MULTIPLE SCLEROSIS THERAPY BY TRANSPLANTATION OF A GENE-CELL VESICULAR THERAPEUTIC DRUG |
2021 |
- Arkhipova Svetlana Sergeevna
- Alatrash Rim
- Garanina Ekaterina Evgenevna
- Rizvanov Albert Anatolevich
|
RU2762855C1 |
