METHOD OF PRODUCING CHIRAL 2-ARYL MORPHOLINES Russian patent published in 2019 - IPC C07D265/30 C12P17/14 C12P7/22

Abstract RU 2677328 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a new method for producing chiral 2-(4-aminophenyl)morpholines of formula .

EFFECT: technical result: a new method of obtaining chiral 2-(4-aminophenyl)morpholines with affinity to trace amine associated receptors (TAARs) has been developed, which includes a step for enzymatic reduction of a ketone of formula to form a chiral alcohol of formula ; with subsequent steps of obtaining the desired product of formula I.

8 cl, 15 ex

Similar patents RU2677328C1

Title	Year	Author	Number
METHOD OF PRODUCING PYRIMIDINYLCYCLOPENTANE COMPOUNDS	2014	Iding, Hans Reents, Reinhard Scalone, Michelangelo Gosselin, Francis	RU2826179C2
METHOD OF PRODUCING PYRIMIDINYLCYCLOPENTANE COMPOUNDS	2014	Iding Khans Reents Rajnkhard Skalone Mikelandzhelo Gosselen Fransis	RU2702355C1
METHOD FOR PRODUCTION OF HYDROXYLATED CYCLOPENTAPYRIMIDINE COMPOUNDS AND THEIR SALTS	2013	Babu Srinivasan Gosselen Fransis Zhan Intsin Remarchuk Trevis Sevidzh Skott Dzh. Stalts Dzheffri Yadzhima Kherbert	RU2642311C2
HETEROCYCLIC DERIVATIVES AS RECEPTORS ASSOCIATED WITH TRACER AMINES (TAARS)	2013	Gallej Guido Gergle Annik Norkross Rodzher Pfliger Filipp	RU2621050C2
SUBSTITUTED BENZAMIDE DERIVATIVES	2010	Grebke Tsbinden Katrin Norkross Rodzher Pfliger Filipp	RU2595902C2
PYRIMIDYL CYCLOPENTANES AS AKT-PROTEIN KINASE INHIBITORS	2008	Benksik Jozef R. Blehjk Dzhejms F. Kallan Nikolas K. Mitchell Jan S. Spenser Kit L. Ksiao Dengming Ksu Rui Chabot Kristin Liang Dzun Safina Brajn S.	RU2486178C2
METHOD OF NEBIVOLOL RACEMATE OBTAINMENT	2006	Bader Tomas Shtutts Al'Fred Khofmajer Kharal'D Bikhzel' Khans-Ul'Rikh	RU2392277C2
SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS	2012	Su Wei-Guo Deng Wei Ji Jianguo	RU2569635C9
METHODS OF SYNTHESIS IF DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES AND INTERMEDIATE COMPOUNDS	1995	Bendzhamin Ehlan Anderson Marvin Martin Khensen Dzheffri Tomas Vichentsi Dehvid Li Vehri Milton Dzhozef Zhmizhevski	RU2151149C1
AMIDINE DERIVATIVES, A METHOD OF THEIR SYNTHESIS AND A DRUG BASED ON SAID SHOWING A PROPERTY TO INHIBIT ACTIVITY OF NITROGEN OXIDE (V) SYNTHETASE	1994	Robert Dzhejms Dzhentajl Robert Dzhon Mjurrej Dzhejms Ehdvin Makdonald Uill'Jam Kehlvin Shejkspir	RU2130017C1

RU 2 677 328 C1

Authors

Trussardi Rene

Iding Khans

Dates

2019-01-16—Published

2014-12-08—Filed