METHOD FOR ESTIMATING MICROCIRCULATORY DISORDERS IN PATIENTS WITH DISORDERS OF CARBOHYDRATE METABOLISM Russian patent published in 2019 - IPC A61B8/06 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to endocrinology, and is intended to identify microcirculatory disorders in patients with impaired carbohydrate metabolism. Method includes an assessment of the level of cutaneous microcirculation of blood with functional test using the method of laser Doppler flowmetry on the hand and the mathematical calculation of indicators for assessing microcirculation based on the data obtained. Functional test is a thermal test, the subject takes a sitting position, puts his or her hands on a horizontal surface in front of him or her, palms down, so that the forearms are at the level of the heart. Sensor for measuring skin microcirculation with a heating element is fixed on the dorsum of the forearm of one of the hands 4 cm proximal to the wrist joint in the midline. Within one minute, the basic level of microcirculation is recorded at a temperature of the heating element of 32–32.4 °C. At the 61^st second, studies include heating to 41.8–42.2 °C with heating rate 2 °C per second, while the temperature of the heating element 41.8–42.2 °C support constant until the end of the sample. Stop registration after 120 seconds after turning on the heat, the result is the microcirculation index values for the period of registration of the level of skin microcirculation. Then calculate the slope of the linear regression function of the microcirculation index, multiplied by 10, for 120 seconds of heating: , where Sl is the slope of the linear regression function; t is a specific point in time; I – the value of the indicator of microcirculation at a particular point in time; – arithmetic average time value for the estimated period; – arithmetic average value of the microcirculation index for the estimated period; n₆₁, n₁₈₀ – numerical values reflecting the number of measurements made on the 61^st and 180^th seconds of registration, respectively, which are calculated using the formula n_t=t⋅ν, where t is the time from the beginning of the study in seconds, a ν – the number of measurements per second. Resulting value of the parameter Sl is substituted into the formula , where P is the probability of the patient having microcirculatory disorders, and the value of the parameter P, whose value ranges from the minimum – 0 to the maximum – 1, assess the probability of the presence of microcirculation disorders in the patient.

EFFECT: invention provides an increase in the accuracy of research, its informativeness, simplicity in implementation, and also allows us to give a quantitative, objective, rapid assessment of the state of cutaneous microcirculation in patients with diabetes.

1 cl, 2 ex