2-PHENYLAMINO-3-CYANOPYRAZOLO[1,5-A]PYRIMIDINE, USEFUL AS INHIBITOR OF LEUKOTRIENE A HYDROLASE Russian patent published in 2019 - IPC C07D487/04 A61K31/519 A61P1/02 A61P1/04 A61P11/00 A61P13/08 A61P13/12 A61P17/00 A61P19/02 A61P21/00 A61P27/02 A61P27/16 A61P29/00 A61P35/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula (I) or to a pharmaceutically acceptable salt thereof, where R is group r is 0; each of R^1a, R^1b, R^1c, R^1d and R^1e independently represents hydrogen; R³ represents -O-; R⁴ is a direct bond; R⁷ is hydrogen; R⁹ is absent; each of R¹⁰ and R¹¹ is independently selected from the group consisting of hydrogen and phenyl, substituted with 1–3 substituents selected from NO₂, OH, OCH₃ and chlorine; R¹⁶ is cyano; R¹⁷ is independently selected from the group consisting of phenyl substituted with one or two substituents selected from NO₂, C(O)OH and S(O₂)CH₃, and pyridyl, substituted C(O)OH, and C(O)R¹⁰, NR¹⁰R¹¹; w is 1. Invention also relates to a pharmaceutical composition based on a compound of formula (I) and a method for treating a disease or disorder that can be alleviated by inhibiting the activity of leukotriene-A₄-hydrolase.

EFFECT: obtaining novel heterocyclic compounds possessing useful biological properties.

17 cl, 2 tbl, 3 ex