AZOLES AS INHIBITORS OF MALONYL-COA-DECARBOXYLASE USEFUL AS METABOLIC MODULATING AGENTS Russian patent published in 2005 - IPC

Abstract RU 2258706 C2

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to methods for treatment of diseases or syndromes associated with metabolism of fatty acids and glucose and to new compounds and their pharmaceutically acceptable salts. Invention relates to applying new compounds and pharmaceutical compositions for treatment of cardiovascular diseases, diabetes mellitus, cancer diseases, acidosis and obesity by inhibition of activity of enzyme malonyl-CoA-decarboxylase. Indicated compounds correspond to formulae (I) and (II) wherein Y, C, R1, R2, R6 and R7 have values given in the invention claim.

EFFECT: valuable medicinal and biochemical properties of azoles.

27 cl, 8 tbl

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RU 2 258 706 C2

Authors

Arrkhenius Tomas

Chehn Tsze Fehj

Uilson Mark

Serafimov Rossi

Dates

2005-08-20Published

2002-02-19Filed