LEUKOTRIENE A4-HYDROLASE INHIBITORS Russian patent published in 2019 - IPC C07C217/58 C07C229/38 C07D211/60 C07D213/62 C07D401/04 C07D401/14 C07D403/14 C07D405/14 C07D413/12 A61K31/395 A61K31/44 A61K31/4439 A61K31/451 A61K31/454 A61K31/4545 A61K31/506 A61K31/517 A61P1/00 A61P11/00 A61P25/00 A61P27/00 A61P29/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where R is group r is 0; R^1a is C₁-C₄ alkyl substituted with OH; halogen; or unsubstituted oxazolyl; R^1b, R^1c, R^1d and R^1e each independently represent hydrogen; R³ is -O-; R⁴ is methylene; R^5a and R^6a each independently represent hydrogen; R⁷ is hydrogen or C₁-C₆ alkyl, optionally substituted with one methoxy group; R⁹ is absent; each R¹⁰ independently represents methyl or ethyl; R¹⁵ is pyridyl substituted with one substitute selected from piperidine substituted with -CO₂H; -NCH₃-CH₂-phenyl-CO₂H; -O-phenyl substituted with -CO₂H and / or -OCH₃; -O-phenyl substituted with -C(O)OR¹⁰; imidazole, substituted with -CO₂H and CH₃; -CH₃N-CH₂-CO₂H; and -NH-CH₂-CH₂-CO₂H. Invention also relates to a pharmaceutical composition based on the compound of formula (I) and a method of treatment based on using the compound of formula (I). (I).

EFFECT: obtaining novel compounds useful for treating a disease or disorder which is amenable to inhibition of leukotriene A₄-hydrolases activity.

22 cl, 6 tbl