COMPOUNDS WITH SPIRO AND AROMATIC RINGS AND APPLICATION THEREOF Russian patent published in 2022 - IPC C07D471/04 A61K31/4985 A61K31/519 A61P35/00 A61P35/02 A61P43/00 C07D487/04 C07D519/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound by the formula I, or to a pharmaceutically acceptable salt, or enantiomer, or tautomer thereof; wherein X₁ and X₂ are independently selected from a bond or CR_aR_b; X₃ constitutes S; X₄ is selected from N or CR_c, and R_a, R_b, and R_c are independently selected from H, an unsubstituted C_1-6alkyl, or an unsubstituted C_1-6alkoxyl; R₁, R₂, R₃, R₄, and R₇ are independently selected from H, an unsubstituted C_1-6alkyl, or an unsubstituted C_1-6alkoxyl; ring A is selected from a substituted or unsubstituted C_5-6aryl, or a substituted or unsubstituted 5-6-membered heteroaryl, wherein the heteroaryl contains 1 or 2 heteroatoms selected from the following atoms: N or S; ring C is selected from a substituted or non-substituted 9-membered bicyclic heterocyclyl, a substituted or unsubstituted C_5-6 monocyclic aryl, a substituted or unsubstituted 5-6-membered monocyclic heteroaryl, or a substituted or unsubstituted 9-membered bicyclic heteroaryl, wherein the heterocyclyl or heteroaryl contains 1-4 heteroatoms selected from the following atoms: N, O, or S; R₅ and R₆ are independently selected from H, -OH, a halogen, a cyano, a substituted or unsubstituted amino, a substituted or unsubstituted C_1-6alkyl, or an unsubstituted C_1-6alkoxyl; n constitutes any integer from 0 to 3; and wherein the term “substituted” relates to one or more hydrogen atoms in the group, substituted with a substitute selected from: halogen, -OH, -NH₂, -NH(unsubstituted C_1-6alkyl), -CN, a halogenated C_1-8alkyl, an unsubstituted C_1-8alkoxyl. Also proposed is a method for producing the compound by the formula I.

EFFECT: compound by the formula I has a higher inhibitory activity against SHP2 and, thus, can be applied to prevent or treat an SHP2-associated disease.

21 cl, 4 tbl, 23 ex