NEUROACTIVE STEROIDS, COMPOSITIONS AND USE THEREOF Russian patent published in 2019 - IPC C07J7/00 C07J43/00 A61K31/57 A61K31/58 A61P25/00 A61P25/08 A61P25/18 A61P25/20 A61P25/24 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), in which A is selected from a group , , , and ; R¹ is -CH₃, -CH₂F, -CHF₂, -CH₂CH₃, -CH₂OCH₃ or -CH₂OCH₂CH₃; R² and R³ is selected independently from -H, halogen, -CH₃, -OCH₃ or -OCH₂CH₃; R⁴ is -CF₃, cyano, -CH₃, -C(O)OR^a or -C(O)NR^bR^c; R^a is -H, or (C₁-C₂)alkyl; each R^b and R^c is independently H; and n is integer from 0 to 1; or when A is (A-3) or (A-5), R¹ is-CH₃, -CH₂F, -CH₂OCN₃ or -CHF₂, and n is equal to 0, then at least one of R² and R³ is not H. Invention also relates to individual compounds, to a pharmaceutical composition, to a method of treating a CNS related disorder associated with GABA function, to a method of treating a seizure, to a method of treating epilepsy, to a method of treating epileptic status.

H(I).

EFFECT: technical result is obtaining novel compounds of formula (I), having properties of modulator GABA_A, which can be useful in treating a CNS related disorder.

32 cl, 71 ex, 4 tbl, 22 dwg