SELECTIVE HDAC6 INHIBITORS, THEIR PRODUCTION METHOD AND THEIR APPLICATION Russian patent published in 2022 - IPC C07D211/86 C07D405/14 C07D405/04 C07D307/16 C07D307/06 A61K31/69 A61K31/435 A61P35/00 

Abstract RU 2772274 C2

FIELD: pharmaceutically acceptable salts.

SUBSTANCE: invention relates to a compound or a pharmaceutically acceptable salt thereof, having the properties of an HDAC6 inhibitor, and a pharmaceutical composition based on them. In the general formula (I) is a single bond or a double bond; n is 0 or 1; each of T1, T2 is independently selected from the group consisting of CH, CH2, -C(=O)- and N; T3 is C or N; each of Z1, Z2, Z3 is independently CH or N; L1 is selected from the group consisting of a single bond, -NH- and -C(=O)-NH-; R1 is selected from the group consisting of C1-3-alkyl, phenyl or 6-membered heteroaryl, each of which is optionally substituted with 1, 2 or 3 R; R2 is -H or F; ring A is selected from the group consisting of oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, 1,3-dioxolanyl and 1,4-dioxanyl; R is F; "hetero" in a 6-membered heteroaryl is -NH-; in any of the above cases, the number of heteroatoms or heteroatomic group is independently selected from 1 or 2.

EFFECT: providing compounds of formula (I) having HDAC6 inhibitory properties.

22 cl, 3 tbl, 3 ex

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RU 2 772 274 C2

Authors

Wu, Hao

Wei, Changqing

Guo, Qiang

Zhang, Guifen

Liu, Bin

Liao, Yonggang

Xiao, Yao

Chen, Shuhui

Dates

2022-05-18Published

2018-01-10Filed