SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS Russian patent published in 2019 - IPC C07C311/46 A61K31/18 A61P29/02 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I or their pharmaceutically acceptable salts, where R¹ represents H, Cl, CH₃, CF₃ or cyclopropyl; R² represents H, F, Cl, CN, CH₃, CF₃ or CHF₂; R³ represents H, F, Cl, CN, CF₃, OCF₃ or CF₂CF₃; R⁴ represents H; R⁵ represents H, F, Cl, CH₃, OCH₃, OCH₂CH₃, OCH₂CH₂CH₃ or OCHF₂; R^5’ represents H, F, Cl, CH₃, OCH₃, OCH₂CH₃, OCH₂CH₂CH₃ or OCHF₂; R⁶ represents H, F or Cl; R^6' represents H, F or Cl and R⁷ represents H, F, Cl, OCH₃, OCF₃, OCH₂CH₃, OCH(CH₃)₂ or OCHF₂, provided what R¹, R², and R³ do not simultaneously represent hydrogen and what R⁵, R^5’, R⁶, R^6’ and R⁷ do not simultaneously represent hydrogen. Also the invention relates to pharmaceutical compositions comprising a sodium channel inhibitor comprising the compounds of the invention, and to methods for using the compositions in the treatment of various disorders and conditions, including pain.

I.

EFFECT: obtained new compounds and pharmaceutical compositions based on them, which can be used in medicine for treatment of pain.

39 cl, 3 tbl, 44 ex