FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry and pharmaceuticals, in particular to the development of a method for the medical treatment of various forms of multiple sclerosis in humans. Subject of the invention is a peptide with the sequence Abu-TGIRIS-Abu-NH2, where Abu is α-aminobutyric acid, which, when administered intravenously to rats, prevents the development in them of an experimental autoimmune encephalomyelitis (EAE) – a common animal model of multiple sclerosis.
EFFECT: method of medical treatment of various forms of multiple sclerosis in humans is proposed.
1 cl, 18 dwg, 6 ex, 9 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE FROM THE COMPOSITION OF THE IMMUNOGLOBULIN HUMAN HEAVY CHAIN, SUITABLE FOR TREATMENT OF MULTIPLE SCLEROSIS | 2016 |
|
RU2646817C1 |
| PEPTIDE ANALOGUES GH-RH WITH OPPOSING ACTION, WAY OF DEPRESSION OF GH LEVEL, WAY OF DEPRESSION OF IGF-INIGF-II LEVEL, APPLICATION FOR INHIBITION OF GROWTH OF CANCER CELLS, PHARMACOLOGICALLY ACCEPTABLE COMPOSITION (VARIANTS) | 2004 |
|
RU2335506C2 |
| ANTAGONISTIC ANALOGUES OF GROWTH HORMONE RELEASING-HORMONE (GH-RH) INHIBITING INSULIN-LIKE GROWTH FACTORS (IGF-I AND -II) | 1999 |
|
RU2235099C2 |
| METHOD OF OBTAINING ABM-TGIRIS-ABU IMMUNOSUPPRESSOR PEPTIDE LABALED BY GD ION | 2017 |
|
RU2681318C1 |
| ANALOGS OF PARATHYROID GLAND HORMONE | 1997 |
|
RU2198182C2 |
| NEUROMEDIN AND SOMATOSTATIN RECEPTOR AGONISTS | 2000 |
|
RU2263680C2 |
| PROMOTING AGENT OF PROLIFERATION OF REGULATORY T-LYMPHOCYTE, AND THEIR PROMOTION METHOD | 2012 |
|
RU2499043C1 |
| GLP-1 ANALOGS | 1999 |
|
RU2288232C9 |
| PEPTIDE VECTORS | 2004 |
|
RU2361876C2 |
| COMBINATION OF PEPTIDES | 2009 |
|
RU2482127C2 |
