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2 682 509

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IPC

A61K47/50(2017-01-01)

A61K31/728(2006-01-01)

A61P35/00(2006-01-01)

C08B37/08(2006-01-01)

(21) (22)

Application

2016139420, 2015-03-10

(24)

Start date

2015-03-10

(22)

Actual filing date

2015-03-10

(45)

Published

2019-03-20

(72)

Inventor

Buffa RadovanBasarabova IvanaNesporova KristinaEhlova TerezaKotland OndrejSedova PetraHromek LeosVelebny Vladimir

(73)

Holder

Contipro A.S.

CONJUGATES OF OLIGOMER OF HYALURONIC ACID OR SALT THEREOF, METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2019 - IPC A61K47/50 A61K31/728 A61P35/00 C08B37/08

Abstract RU 2682509 C2

FIELD: chemistry.

SUBSTANCE: invention relates to conjugate of hyaluronic acid oligomer or its pharmaceutically acceptable salts according to any of general formulas I, II, III or IV:

where R¹-R⁵, X and substrate are defined in claim 1. Invention also relates to methods of producing said conjugates and to a hyaluronic acid oligomer conjugate, selected from: conjugate of octasaccharide GK (GK-8) with dihydrazid adipate, conjugate of GK (GK-3) trisaccharide with dihydrazidadipate, conjugate of octadec GK (GK-18) with dihydrazidipate, conjugate of GK (GK-4) tetrasaccharide with terephthaloyl dihydrazide.

EFFECT: technical result is obtaining conjugates of hyaluronic acid oligomer or its pharmaceutically acceptable salts, which provide release of oligomers in their native form and show increased biological activity relative to selected lines of cancer cells.

20 cl, 1 dwg, 12 ex

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RU 2 682 509 C2

Authors

Buffa Radovan

Basarabova Ivana

Nesporova Kristina

Ehlova Tereza

Kotland Ondrej

Sedova Petra

Hromek Leos

Velebny Vladimir

Dates

2019-03-20—Published

2015-03-10—Filed