HYALURONIC ACID DERIVATIVE, METHOD OF ITS PRODUCTION, METHOD OF ITS MODIFICATION AND ITS APPLICATION Russian patent published in 2018 - IPC A61K31/728 C08B37/00 C08G81/00 

FIELD: chemistry; medicine.

SUBSTANCE: present invention relates to a hyaluronic acid derivative, a process for its production and use in bio medicine. Proposed is a hyaluronic acid derivative according to the structural formula X or a hydrated form thereof with the structural formula Y:

,

where R is H, tetra-C₁-C₆-alkylammonium or a metal cation, a molecular weight of from 1 to 500 kDa. Proposed derivative can be obtained by hyaluronic acid dehydrating, oxidized to aldehyde at the glucosamine unit position 6, in the glucosamine unit positions 4 and 5 in a water / polar aprotonic solvent mixture at a temperature of from 30 to 80 °C. Hyaluronic acid derivative can be modified by reaction with an amine of the general formula H₂N-R², where R² is a linear or branched C₁-C₃₀-alkyl; either with an amino acid or a peptide; either with a polymer.

EFFECT: proposed are new derivatives, which can be effectively used as biologically active substances carriers in cosmetics and pharmaceuticals, for obtaining of tissue engineering materials and biomedical applications.

15 cl, 21 ex, 1 tbl, 1 dwg