UNSATURATED DERIVATIVES OF POLYSACCHARIDES, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C08B37/00 A61K31/726 A61K31/728 A61K31/731 A61K31/737 A61P35/00 A61P39/06 

Abstract RU 2725500 C1

FIELD: biotechnology.

SUBSTANCE: group of inventions relates to production of new polysaccharide derivatives containing in their structure a heterocycle having a double bond in positions 4 and 5 in accordance with structural formula X

,

where R is -NH-CO-CH3 or -OH. Method of producing consists in oxidation of OH group in position 6 to aldehyde, followed by elimination, aimed at formation of double -C=C-link in positions 4 and 5, and final reduction of aldehyde group in position 6 to initial alcohol.

EFFECT: obtained polysaccharide derivatives show high antioxidant activity, and derivatives based on hyaluronic acid are also characterized by selective negative action on viability of carcinoma cells.

14 cl, 2 dwg, 27 ex

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RU 2 725 500 C1

Authors

Buffa, Radovan

Bobula, Tomas

Sedova, Petra

Basarabova, Ivana

Prochazkova, Pavlina

Vagnerova, Khana

Doleskova, Iva

Moravchikova, Sona

Velebnij, Vladimir

Dates

2020-07-02Published

2017-06-26Filed