SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF Russian patent published in 2020 - IPC C07D471/14 C07D471/20 C07D491/22 C07D498/14 C07D513/14 C07D519/00 C07F7/18 C07F9/6561 A61K31/53 A61K31/5383 A61K31/542 A61K31/675 A61P31/16 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. In formula (I) P is hydrogen or group P^R, selected from following formulas: a) -C(=O)-P^R0, b) -C(=O^)-P^R1, g) -C(=O)-O-P^R2, h) -C(=O)-N(-K)(P^R2), i) -C(=O)-O-L-O-P^R2, l) -C(P^R3)₂-O-C(=O)-P^R4, m) -C(P^R3)₂-O-C(=O)-O-P^R4, v) -C(P^R3)₂-P^R6, y) -C(P^R3)₂-N(-K)-C(=O)-O-P^R2, z) -P(=O)(-P^R8)(-P^R9) and ab) -P^R11, A¹ is CR^1AR^1B; A² is CR^2AR^2B; A³ is CR^3AR^3B, S or O; each of A⁴ independently represents CR^4AR^4B; number of heteroatoms among atoms forming a ring, which consists of A¹, A², A³, A⁴, nitrogen atom adjacent to A¹, and a carbon atom adjacent to A⁴, is 1 or 2; group represented by formula represents a group represented by formula , values of other radicals are given in claim. Invention also relates to individual compounds.

EFFECT: technical result is obtaining novel compounds of formula (I) inhibiting activity of cap-dependent endonuclease and which can be used in treating influenza virus.

11 cl, 2 dwg, 40 tbl, 39 ex