IMMUNOGENIC MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-CoV) COMPOSITIONS AND METHODS Russian patent published in 2019 - IPC A61K39/215 

FIELD: biotechnology.

SUBSTANCE: invention provides a composition for stimulating an immune response against MERS-CoV, containing (i) an effective amount of MERS-CoV nanoparticles, where the nanoparticle contains at least one trimer of Spike polypeptide, and (ii) a saponin-based adjuvant, wherein the saponin-based adjuvant consists of Matrix M1. Invention also relates to a method of producing a high-affinity human antibody against MERS-CoV, comprising administering an immunogenic composition comprising a MERS-CoV nanoparticle and Matrix M1 adjuvant to a transgenic animal, where the nanoparticle contains at least one trimer of Spike polypeptide, wherein the transgenic animal is selected from the group consisting of a cow, a horse, a pig, a sheep, and a goat; collecting serum and / or plasma from the animal and purifying antibodies from the serum and / or plasma.

EFFECT: invention widens the range of medicines in relation to MERS-CoV.

21 cl, 14 dwg, 2 tbl, 4 ex