FIELD: medicine.
SUBSTANCE: there are presented an expression system for high gene expression including a promoter, and at least one MAR sequence; an isolated and purified nucleic acid molecule representing a MAR sequence; a cell; a transgenic animal; a kit for high expression, as well as the use of said expression system for increased protein production.
EFFECT: invention may be used for producing a wide range of proteins including antibodies and interferons by transgenic animals and cell cultures.
7 cl, 15 dwg, 5 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DNA THAT INCREASES PROTEIN PRODUCING AND ITS APPLICATION | 2004 |
|
RU2375450C2 |
| IMPROVED TRANSGENE EXPRESSION AND PROCESSING | 2014 |
|
RU2808756C1 |
| NEW METHODS TO CHARACTERIZE COMPOUNDS STIMULATING STF-I EXPRESSION IN THE CELLS OF PANCREATIC INSULAE | 1997 |
|
RU2183465C2 |
| SELF-AMPLIFYING PHARMACOLOGICALLY CONTROLLABLE EXPRESSIVE SYSTEMS | 1997 |
|
RU2197993C2 |
| EPIGENETIC REGULATORY COMPLEX OF GENE EXPRESSION CONTROL | 2007 |
|
RU2462512C2 |
| NUCLEIC ACID SYNTHETIC MOLECULE (VERSIONS), MAMMAL CELL EXPRESSION VECTOR, MAMMAL HOST CELL AND METHOD OF EXPRESSING ANTIGEN PROTEIN OF HUMAN EPIDERMAL GROWTH FACTOR-2 (HER2/neu) OR SHORTENED FORM THEREOF | 2004 |
|
RU2397249C2 |
| NEW CHROMOPHORES/FLUOROPHORES AND USES THEREOF | 2002 |
|
RU2303600C2 |
| RECOMBINANT EXPRESSION VECTOR ELEMENTS (REVES) TO ENHANCE EXPRESSION OF RECOMBINANT PROTEINS IN HOST CELLS | 2008 |
|
RU2518340C2 |
| METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE | 2014 |
|
RU2693891C1 |
| SYSTEM FOR STIMULATION OF GENES EXPRESSION AND VECTOR CONTAINING SAID SYSTEM | 2010 |
|
RU2577971C2 |
