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2 686 687

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(51)

IPC

G01N33/574(2006-01-01)

C12Q1/6806(2018-01-01)

C12Q1/6876(2018-01-01)

(21) (22)

Application

2018140139, 2018-11-13

(24)

Start date

2018-11-13

(22)

Actual filing date

2018-11-13

(45)

Published

2019-04-30

(72)

Inventor

Kit Oleg IvanovichSoldatova Kristina IgorevnaKolesnikov Evgenij NikolaevichKutilin Denis Sergeevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Issledovatelskij Onkologicheskij Institut" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

METHOD FOR PREDICTION OF LIVER METASTASES IN PATIENTS WITH COLON CANCER Russian patent published in 2019 - IPC G01N33/574 C12Q1/6806 C12Q1/6876

Abstract RU 2686687 C1

FIELD: medicine.

SUBSTANCE: invention refers to molecular oncology, and aims at predicting development of liver metastases in patients with colon cancer. Summary RNA is extracted from tissue samples by guanidine-thioniate-phenol-chloroform extraction method. MAGEB1, SSX2, SCP1, GAPDH and GUSB genes are real-time amplified. Relative expression of the genetic loci and the geometrical reference gene GAPDH and GUSB are calculated. Gene expression coefficient - K_MAGEB1, K_SSX2, K_SCP1. At values of K_MAGEB1> 2.2±0.5, K_SSX2> 2.2±0.4 and K_SCP1<2.7±0.6, the absence of metastases is predicted. At values of K_MAGEB1<0.4±0.2, K_SSX2<0.7±0.3 and K_SCP1> 8.5±0.8 predicts development of metastases. Values between said intervals are considered to be undefined.

EFFECT: invention provides creating a new, easy-to-implement, inexpensive and more accurate method for predicting the development of liver metastases in patients with colon cancer.

1 cl, 1 tbl, 2 ex

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RU 2 686 687 C1

Authors

Kit Oleg Ivanovich

Soldatova Kristina Igorevna

Kolesnikov Evgenij Nikolaevich

Kutilin Denis Sergeevich

Dates

2019-04-30—Published

2018-11-13—Filed