FIELD: medicine.
SUBSTANCE: application of nitrosyl iron complex with N-ethylthiourea of composition [Fe(SR)2(NO)2]Cl⋅[Fe(SR)Cl(NO)2], where R = C(NH2)(NHC2H5), as an antitumour agent for NO tumor therapy selected from carcinosarcoma Hs578T, invasive hormone-dependent erbb2-amplifying carcinoma of ducts of mammary gland BT-474, adenocarcinoma of human rectum Caco2 and glioblastoma A-172.
EFFECT: technical result: the declared complex causes cell death of the listed tumours, wherein is nontoxic in relation to normal cells.
1 cl, 9 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| MONONECLEAR DINITROSYL FERRIC COMPLEXES, METHOD FOR PREPARING MONONECLEAR DINITROSYL FERRIC COMPLEXES, NITROGEN MONOXIDE DONOR, USING MONONECLEAR DINITROSYL FERRIC COMPLEXES AS ANTI-TUMOUR DRUG | 2011 |
|
RU2494104C2 |
| SINGLE-NUCLEAR CATIONIC DINITROSYL IRON COMPLEXES, METHOD FOR PRODUCING THEM, NITROGEN MONOXIDE DONOR | 2014 |
|
RU2567245C1 |
| BINUCLEAR NITROSYL IRON COMPLEXES WITH BENZAZEHETEROCYCLIC DERIVATIVES, WAYS OF ITS PRODUCTION | 2007 |
|
RU2441872C2 |
| WATER-SOLUBLE BINUCLEAR CATION NITROSYL IRON COMPLEXES WITH NATURAL ALIPHATIC THIOLYLS POSSESSING CYTOTOXIC, APOPTOTIC AND NO-DONOR ACTIVITY | 2008 |
|
RU2441873C2 |
| SUPRAMOLECULAR ASSEMBLIES OF DINITROSYL IRON COMPLEXES, METHOD OF THEIR PREPARATION, NITROGEN MONOXIDE DONORS, PHOSPHODIESTERASE INHIBITORS, USE OF SUPRAMOLECULAR ASSEMBLIES OF DINITROSYL IRON COMPLEXES AS ANTI-INFLAMMATORY MEDICINAL PRODUCTS | 2023 |
|
RU2814108C1 |
| USE OF BINUCLEAR SULPHUR-NITROSYL CATIONIC IRON COMPLEX AS VASODILATATOR | 2010 |
|
RU2460531C2 |
| USING TETRANITROSYL COMPLEX OF IRON WITH THIOPHENOL AS ANTI-TUMOUR MEDICINAL AGENT | 2007 |
|
RU2429242C2 |
| AGENT WITH ANTIVIRAL ACTIVITY AGAINST SARS-COV-2 AND METHOD OF USING THE SAME | 2022 |
|
RU2797619C1 |
| PHARMACEUTICAL ANTITUMORAL COMPOSITION OF PACLITAXEL WITH HISTONE N1.3 AS A CARRIER AND A METHOD FOR PREPARING THE COMPOSITION | 2017 |
|
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| APPLICATION OF BINUCLEAR SULPHUR-NITROSYL COMPLEX OF ANION TYPE IRON AS VASODEPRESSOR MEDICATION | 2010 |
|
RU2437667C1 |
