FIELD: immunology.
SUBSTANCE: present invention relates to immunology. Disclosed an antibody and its antigen-binding fragment, which specifically bind to PcrV Pseudomonas, as well as a bispecific antibody containing a domain, which binds Psl Pseudomonas, and a domain which binds to PcrV Pseudomonas. Invention also describes: a polynucleotide molecule coding the antibody according to the invention; composition containing the disclosed antibody, and a method for preventing or treating an infection caused by Pseudomonas.
EFFECT: present invention can find further application in therapy.
15 cl, 35 dwg, 20 ex, 7 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| MOLECULES WHICH BIND TO PSL PSEUDOMONAS, AND METHODS FOR USE THEREOF | 2012 |
|
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| IMMUNOGENIC COMPOSITIONS | 2018 |
|
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|
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| ANTIBODIES TO S. AUREUS SURFACE DETERMINANTS | 2013 |
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| BINDING MOLECULES SPECIFIC FOR ASCT2, AND THEIR USE | 2016 |
|
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| BINDING MOLECULE SPECIFIC FOR HER3, AND THEIR APPLICATIONS | 2012 |
|
RU2620068C2 |
| ANTIBODIES TO SURFACE DETERMINANTS OF S. AUREUS | 2013 |
|
RU2808018C2 |
| HUMANISED ANTIBODIES TO OX40 AND METHODS FOR USE THEREOF | 2015 |
|
RU2709742C2 |
