SINGLE-DOSE PHARMACEUTICAL PREPARATION OF THYROID HORMONES T3 AND/OR T4 Russian patent published in 2019 - IPC A61K38/29 A61K9/48 A61J3/07 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to medicine and concerns a single-dose pharmaceutical preparation of thyroid hormones T3 and/or T4 suitable for oral administration in a ready-to-use package. Said package consists of container pre-filled with water-alcohol solution of thyroid hormone T3 and/or thyroid hormone T4. Container is a single-component plastic container of low-density polyethylene (LDPE) with nominal volume of 1 ml, compressible hand and having a Young's modulus of 10 to 200 MPa, placed in a sealed sachet consisting of a multilayer film made of materials in the following combination: polyethylene with thickness of 50 mcm (± 5–6 %), aluminium with thickness of 9 mcm (± 5–6 %) and polyester with thickness of 12 mcm (± 5–6 %); wherein said sachet package exhibits permeability with respect to oxygen and water vapour in range of 0.1 to 0.2 cm³/m²/day. Invention also discloses use of the preparation in a ready-to-use package for treating diseases associated with deficiency of the thyroid hormone T3 and/or T4.

EFFECT: group of inventions provides stability of water-alcohol solution of thyroid hormone T3 and/or thyroid hormone T4.

6 cl, 17 tbl, 8 ex