HETEROARYL-SUBSTITUTED PYRAZOLE-PYRIDINE PROTEIN KINASE INHIBITORS FOR STIMULATING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH Russian patent published in 2025 - IPC C07D471/04 A61K31/437 A61K31/444 A61K31/506 A61P1/16 A61P19/02 A61P25/00 A61P25/28 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (Ia), or a pharmaceutically acceptable salt thereof, which selectively inhibit mitogen-activated protein kinase 4 (MKK4) compared to protein kinases JNK1 and MKK7. In formula (Ia) R¹ is H; R⁴ is H; R⁵ is selected from a) pyrimidinyl, which is substituted with 1 or 2 substituents independently selected from C₃-C₆-cycloalkyl, C₁-C₄-alkyl, -COOR¹⁰, -OH, C₁-C₄-alkylsulfanyl, tetrazolyl, CN, halogen and C₁-C₄-alkoxy, and b) pyridyl, which is substituted with 1 or 2 substituents independently selected from C₁-C₄-alkyl and halogen; R⁶ is H; R^w is -NR¹⁰SO₂R¹²; R^x is F; R^y is F; R^z is H or F; R¹⁰ in each case is independently H or C₁-C₄-alkyl; R¹² is C₁-C₄-alkyl or phenyl-C₁-C₄-alkyl. Invention also relates to specific compounds, pharmaceutical compositions for selective inhibition of protein kinase MKK4 compared to protein kinases JNK1 and MKK7, to stimulate liver regeneration and to reduce or prevent death of hepatocytes and to use of said compounds for preparing such pharmaceutical compositions.

EFFECT: disclosed are heteroaryl-substituted pyrazole-pyridine protein kinase inhibitors for stimulating liver regeneration or reducing or preventing hepatocyte death.

14 cl, 1 tbl, 38 ex