COMPOSITIONS OF CGRP RECEPTOR ANTAGONISTS Russian patent published in 2019 - IPC A61K31/4545 A61K9/08 A61K47/10 A61K47/22 A61K47/26 A61P25/06 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceuticals, specifically: a liquid pharmaceutical composition for treating migraine headache comprising (S)-N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide, or a pharmaceutically acceptable salt or hydrate thereof in amount of 0.01 to 3.0 wt. % of the composition and a pharmaceutically acceptable carrier comprising at least one water-soluble surfactant, selected from the group consisting of VitE-TPGS, poloxamer, Tween 20, Tween 80 or Span 20 and combinations of two or more of the listed; as well as to methods of treating migraine headache.

EFFECT: group of inventions provides preparing liquid pharmaceutical compositions of a CGRP receptor antagonist which do not contain alcohol and can be used without water for treating a migraine headache without depositing an active agent in the oral cavity.

17 cl, 4 ex, 6 tbl