ISOINDOLONES AND METHODS FOR USING THEM Russian patent published in 2013 - IPC C07D209/46 C07D209/44 A61K31/4035 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to isoindolones of formula 1: or pharmaceutically acceptable salts thereof, wherein: Z¹ means CR¹R^1a; R¹ and R^1a independently mean H; Z² means CR²; R² means H; Z³ means CR³; R³ means H; R⁴ means H; Y means W-C(O); W means R⁵ means H; X¹ means -OR^11'; R^11' independently means H, C₁-C₁₂-alkyl which may be substituted by one -(CR¹⁹R²⁰)_nOR¹⁶, wherein R¹⁶ means H; R⁶ and R^6' independently mean H, halogen; provided both R⁶ and R^6' mean other than H simultaneously; n and p are is equal to 0, 1, 2 or 3; R¹⁹ and R²⁰ independently mean H.

EFFECT: compounds inhibit the abnormal cell growth that enables using them to prepare the pharmaceutical composition effective for treating a hyperproliferative disease in a mammal.

8 cl, 5 dwg, 5 ex