FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a composition for use in treating glioblastoma, wherein said composition comprises: (a) an effective amount of an antibody, an antibody fragment or diapers, which has B7-H3 specificity, and (b) an effective amount of an antibody or an antibody fragment which has specificity for VEGF or VEGFR. Invention also relates to use of an antibody, an antibody fragment or diapers, which has B7-H3 specificity, in combination with an antibody or antibody fragment which has specificity for VEGF or VEGFR, for treating glioblastoma, wherein the use provides: a) administering an effective amount of said antibody, antibody fragment or diapers, having B7-H3 specificity, and an effective amount of said antibody or antibody fragment having VEGF or VEGFR specificity simultaneously; or b) administering an effective amount of one of said antibody, antibody fragment or diapers, which has B7-H3 specificity, and an effective amount of said antibody or antibody fragment, which has specificity for VEGF or VEGFR, and then introduction of the other of said antibody, antibody fragment or diapers, which has B7-H3 specificity, or said antibody or antibody fragment, which has VEGF or VEGFR specificity, within 10 half-lives after administration of the first of said antibody, antibody fragment or diapers, which has specificity for B7-H3, or said antibody or antibody fragment, which has specificity with respect to VEGF or VEGFR.
EFFECT: disclosed composition has improved efficacy against glioblastoma.
9 cl, 2 ex, 9 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| COMBINED THERAPY FOR CANCER TREATMENT | 2016 |
|
RU2731202C2 |
| TRISPECIFIC BINDING MOLECULES, WHICH SPECIFICALLY BIND ANTIGENS OF A VARIETY OF MALIGNANT TUMORS, AND METHODS OF USING THEM | 2015 |
|
RU2718692C2 |
| METHODS OF TREATING CANCER USING PD-1 AXIS BINDING AND VEGF ANTAGONISTS | 2013 |
|
RU2689760C2 |
| ANTI-B7-H3-ANTIBODY | 2012 |
|
RU2668170C2 |
| BISPECIFIC BINDING MOLECULES CAPABLE OF BINDING CD137 AND TUMOR ANTIGENS AND VARIANTS OF THEIR APPLICATION | 2018 |
|
RU2805648C2 |
| COMBINED THERAPY FOR MALIGNANT TUMOR TREATMENT | 2016 |
|
RU2733315C2 |
| ANTIBODY AGAINST B7-H3, ITS ANTIGEN-BINDING FRAGMENT AND THEIR MEDICAL USE | 2018 |
|
RU2765306C2 |
| VARIANT CD3 BINDING DOMAINS AND THEIR USE IN COMBINATION THERAPY FOR TREATMENT OF DISEASES | 2019 |
|
RU2810222C2 |
| ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) | 2013 |
|
RU2639506C2 |
| ANTI-PD-1 ANTIBODIES | 2017 |
|
RU2752832C2 |
