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(19)

(11)

2 668 170

(13)

(51)

IPC

C07K16/28(2006-01-01)

C12N15/13(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

C12N5/10(2006-01-01)

C12N15/63(2006-01-01)

(21) (22)

Application

2013152164, 2012-04-24

(24)

Start date

2012-04-24

(22)

Actual filing date

2012-04-24

(45)

Published

2018-09-26

(72)

Inventor

Takakhasi SuMatsuoka TatsudziMurakami KendziTakizava TakesiKhirotani KendziUrano AtsusiFukuti KejsukeYadzava Mitsukhiro

(73)

Holder

Dajiti Sankio Kompani, Limited

ANTI-B7-H3-ANTIBODY Russian patent published in 2018 - IPC C07K16/28 C12N15/13 A61K39/395 A61P35/00 C12N5/10 C12N15/63

Abstract RU 2668170 C2

FIELD: chemistry.

SUBSTANCE: invention relates to immunology. Disclosed is an antibody which binds to B7-H3 and has activity in antibody-dependent cellular phagocytosis (ADCP) and antitumour activity in vivo. Polynucleotide, a vector, a host cell and a method of producing an antibody of the invention using same are also disclosed. In addition, pharmaceutical compositions and methods for treating a tumour are provided.

EFFECT: present invention can find further application in the treatment of various diseases.

40 cl, 67 dwg, 4 tbl, 12 ex

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RU 2 668 170 C2

Authors

Takakhasi Su

Matsuoka Tatsudzi

Murakami Kendzi

Takizava Takesi

Khirotani Kendzi

Urano Atsusi

Fukuti Kejsuke

Yadzava Mitsukhiro

Dates

2018-09-26—Published

2012-04-24—Filed