FIELD: medicine.
SUBSTANCE: invention refers to clinical and experimental medicine, namely to hepatology, transplantology, and can be used for treating hepatic insufficiency. Method involves blood exfusion into the extracorporeal circuit, filtration with blood plasma cell separation from the plasma, perfusion of blood plasma through hepatocyte cell culture, mixing of the treated plasma with blood cells and return to the patient. Novelty is that additionally after filtration of plasma it is proposed to perform separation of its components on membrane with pore size of 35–45 nm, and in blood plasma perfusion, the cell culture used is the autoculture of liver cells in amount of 2–2.5 g per kilogram of body weight fixed on the biomatrix with a synthetic base of biocompatible polymers. Serum is separated and perfused at a flow rate of 10–20 ml/min.
EFFECT: technical result consists in higher clinical effectiveness in liver failure in patients, including in acute phase.
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