METHOD FOR PREDICTION OF PATHOLOGICAL SCAR FORMATION ACCOMPANYING WOUND HEALING Russian patent published in 2019 - IPC A61B5/00 G01N21/64 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to reconstructive surgery, and can be used for prediction of formation of a pathological scar in wound healing. Laser examination by laser fluorescence spectroscopy using a source at wavelength λ_e=365 nm. Examination is performed for the first time in period from 6th to 9th days and the second time from 17th to 21st day after the operation. Fluorescence intensity values of collagen and elastin I_f are determined and backscattered radiation intensity I_e value, reduced by light filter in β~10³ times. Obtained data are used to define an index of tissue content of collagen and elastin of the surgical wound η_p and intact tissue η_u by known formula. Then indices of tissue content of collagen and elastin μ_n when performing the n day study and μ_m, during studies for m days by formula μ_n(m)=η_p/η_u, where n is the day of the first study in 6–9th postoperative day, am is the day of the second study in 17–21st day period. If value of ratio μ_n/μ_m≤0.35, development of a keloid cicatrix is predicted, at 0.35<μ_n/μ_m<0.6 – developing hypertrophic scar, and if μ_n/μ_m>0.6 predicting formation of normotrophic scar.

EFFECT: method provides a postoperative assessment of skin condition by determining the tissue content of collagen and elastin of the surgical wound and intact tissue.

1 cl, 4 ex