ISOINDOLINE DERIVATIVE, ITS PHARMACEUTICAL COMPOSITION AND USE Russian patent published in 2023 - IPC C07D401/14 A61K31/496 A61P35/00 

FIELD: organic chemistry.

SUBSTANCE: group of inventions includes an isoindoline derivative of general formula (I), its pharmaceutically acceptable salt, stereoisomer, a method of production of a pharmaceutical composition based on it and its use. In Formula (I), R₁ and R₂ are each independently selected from H and halogen, provided that R₁ and R₂ are not both H; X represents O; each of X₁, X₂ is independently selected from C or N; each of X₃, X₄ and X₅ represents C; each of R₄, R₅, R₆, R₇ and R₈ is independently absent or selected from H, halogen, unsubstituted (C₁-C₁₂)alkyl or substituted with 1–3 halogens, unsubstituted (C₁-C₁₂)alkoxy group or substituted with 1–3 substituents selected from D, halogen or (C₃-C₆)cycloalkyl, unsubstituted (C₃-C₆)cycloalkyl, -CH=CH₂, -C≡ CH, -CN, -OH, -NO₂, or where each of R₉ and R₁₀ is independently selected from H or unsubstituted (C₁-C₁₂ )alkyl, provided that at least one of R₄, R₅, R₆, R₇ and R₈ is selected from -CN, -NO₂, -CH=CH₂, -C≡ CH, (C₁-C₁₂)alkyl substituted with 1–3 halogens, (C₁-C₁₂)alkoxy group substituted with 1–3 halogens, or (C₁-C₁₂)alkoxy group substituted with 1–3 D.

EFFECT: obtaining isoindoline derivative of General formula (I), used for the treatment of multiple myeloma.

15 cl, 2 tbl, 29 ex