ASSOCIATED WITH PARAINFLUENZA-3 VACCINE, INFECTIOUS RHINOTRACHEITIS, VIRAL DIARRHEA, ROTA- AND CORONAVIRAL INFECTIONS OF CATTLE INACTIVATED EMULSION Russian patent published in 2019 - IPC A61K39/155 A61K39/265 A61K39/215 A61K47/10 A61K47/44 A61P31/00 

FIELD: veterinary medicine.

SUBSTANCE: invention refers to veterinary virology and biotechnology, particularly to parainfluenza-3-associated vaccines, infectious rhinotracheitis, viral diarrhea, rota- and coronaviral infections in cattle. Vaccine contains, as an active substance, a mixture of inactivated and concentrated antigens of strain "PTK-45/86" of parainfluenza-3, strain "TK-A (VIEV)-V2" of infectious rhinotracheitis virus, strain "VK-1" of viral diarrhea virus – disease of mucous membranes of cattle, strain "RM" of rotavirus and strain 2-"CL-2" of bovine coronavirus with activity of each of strains not less than 8.0 Lg TCD 50/cm³, taken in volume ratio of 1:1:1:1:1. As an adjuvant contains a mixture of synthetic oil PES-3M and lanolin anhydrous, taken in ratio 85:15, wherein for preparing the series of the associated vaccine, the oil adjuvant is mixed in a volume ratio of 1:1 with a mixture of concentrated viral antigens.

EFFECT: invention enables to preserve the biological properties of vaccine for 12 months.

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