FIELD: biotechnology.
SUBSTANCE: chimeric recombinant protein MGL-M456 for therapy of oncological diseases, consisting of L-methionine-gamma-lyase fused with VHH antibody BCD090-M456 is presented. Also disclosed is a genetic construct coding said chimeric protein.
EFFECT: group of inventions can be effectively used for therapy of oncological diseases.
2 cl, 2 dwg, 2 ex
Title | Year | Author | Number |
---|---|---|---|
CHIMERIC ENZYME MGL-S3 - METHIONINE-GAMMA-LYASE FUSED WITH S3 DOMAIN OF VGF PROTEIN FROM VACCINIA VIRUS, METHOD FOR PRODUCING MGL-S3 AND ANTICANCER PREPARATION BASED ON THIS ENZYME | 2022 |
|
RU2816486C2 |
METHOD OF PRODUCING A METHIONINE-GAMMA-LYASE ENZYME, AN ANTITUMOR DRUG FDF MGL BASED ON SAID ENZYME AND USE OF SAID AGENT FOR TUMOR GROWTH INHIBITION (VERSIONS) | 2018 |
|
RU2733440C2 |
METHOD OF PRODUCING DIALKYL THIOSULPHINATES USING TWO-COMPONENT SYSTEM OF METHIONINE-γ-LYASE + S-ALKYL-L-CYSTEINE SULPHOXIDES | 2021 |
|
RU2814985C2 |
GENE OF PEPTIDE-FORMING ENZYME, PEPTIDE-FORMING ENZYME AND METHOD FOR PRODUCTION OF DIPEPTIDE | 2002 |
|
RU2280077C2 |
PHARMACEUTICAL COMPOSITION CONTAINING ERYTHROCYTES IN WHICH AN ENZYME DEPENDENT ON PYRIDOXALPHOSPHATE IS ENCLOSED, AND COFACTOR THEREOF | 2015 |
|
RU2697086C2 |
PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES CONTAINING ENZYME DEPENDENT ON PYRIDOXALPHOSPHATE AND COFACTOR THEREOF | 2015 |
|
RU2744659C2 |
RECOMBINANT PLASMID pET-15b_T1_RL DNA PROVIDING SYNTHESIS OF RECOMBINANT FUSION PROTEIN CONSISTING OF TUMOR-SPECIFIC PEPTIDES AND ANTITUMOR PEPTIDE RL2, AND RECOMBINANT FUSION PROTEIN POSSESSING CYTOTOXIC ACTIVITY AGAINST CANCER CELLS AND TARGETED PROPERTIES AGAINST TUMOR TISSUE | 2016 |
|
RU2619050C1 |
PSCA-CAR-YT CELL LINE HAVING SURFACE EXPRESSION OF CHIMERIC ANTIGEN RECEPTORS AND EXHIBITING CYTOTOXIC ACTIVITY ON PSCA-POSITIVE HUMAN CANCER CELLS | 2018 |
|
RU2712901C1 |
RECOMBINANT VESICULAR STOMATITIS VIRUS EXPRESSING CHIMERIC IL12-GMCSF PROTEIN | 2022 |
|
RU2817896C1 |
SINGLE-DOMAIN LLAMA ANTIBODY H5 AND ITS DERIVATIVE H5-Fc SPECIFICALLY BINDING THE RBD DOMAIN OF THE S-PROTEIN OF THE SARS-CoV-2 VIRUS POSSESSING VIRUS-NEUTRALIZING ACTIVITY | 2022 |
|
RU2793967C1 |
Authors
Dates
2024-02-19—Published
2022-12-23—Filed