BIOMARKERS FOR TUBERCULOSIS Russian patent published in 2019 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and can be used for detecting tuberculosis in a subject. That is ensured by determining the level of one or more biomarkers selected from a group consisting of an interleukin-1 (IL-1Ra) receptor antagonist in a sputum sample obtained from a subject, interleukin-10 (IL-10), interleukin-13 (IL-13), interleukin-15 (IL-15), fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF) and vascular endothelioma growth factor (VEGF). That is followed by comparing the levels of the biomarkers with the reference values. Reduced level of IL-1Ra, IL-10, IL-13, IL-15, G-CSF and/or VEGF in the sputum sample as compared to the reference value(s), and/or an increased level of FGF in the sputum sample compared to the reference value is an indicator of the presence of tuberculosis in the individual. Also disclosed are a method of treating a subject suspected of suffering a pulmonary disease, and using an apparatus for immunochromatographic analysis for detecting tuberculosis in a subject.

EFFECT: group of inventions enables detecting presence or absence of tuberculosis in a subject by measuring levels of biomarkers in a sputum sample as compared to reference values.

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